CRYPTOCOCCAL INFECTIONS IN PATIENTS WITH AIDS
《CRYPTOCOCCAL INFECTIONS IN PATIENTS WITH AIDS》內(nèi)容預(yù)覽
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《CRYPTOCOCCAL INFECTIONS IN PATIENTS WITH AIDS》內(nèi)容簡(jiǎn)介
CRYPTOCOCCALINFECTIONSINPATIENTSWITHAIDS
StephenJ.Gluckman,M.D.
Botswana-UPENNPartnership
Microbiology
lEncapsulatedyeast
l4serotypes
lA(C.neoformansvgrubii)
lBandC(C.gatti)
lD(C.neoformansvneoformans)
lAlltypescancausehumandisease
lLifecycle
lAsexual:yeastthatreproducebybudding
lHumaninfections
lSexual:onlyseeninthelaboratory
EcologyandEpidemiology
lWorldwide
lC.neoformansassociatedwithbirddroppings
lC.gattinotassociatedwithbirds,associatedwitheucalyptustrees
lGenerallyaninfectionofimmunocompromisedbutcancauseclinicaldiseaseinhealthypersons
lDecreasedCell-mediatedimmunity
lAIDS–CD4usually<100
lProlongedcorticosteroids
lOrgantransplant
EcologyandEpidemiology
l15-30%ofAIDSpatientsinSub-SaharanAfrica*
lMuchlesscommoninchildren
lNopersontopersontransmission
*Powderly,WGClinInfectDis1993
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